منابع مشابه
The Architecture of Parent-of-Origin Effects in Mice
The number of imprinted genes in the mammalian genome is predicted to be small, yet we show here, in a survey of 97 traits measured in outbred mice, that most phenotypes display parent-of-origin effects that are partially confounded with family structure. To address this contradiction, using reciprocal F1 crosses, we investigated the effects of knocking out two nonimprinted candidate genes, Man...
متن کاملParent of origin effects in obesity in the Sorbs
Parent of origin effects (POE) which could explain part of heritability in obesity were studied. The candidate gene FTO (fat mass and obesity associated) was selected from the Sorbs, a selfcontained population from eastern Germany. We hypothesized there were variants within robustly replicated FTO that conferred different risk of obesity depending on the parental origins of alleles. Genotypes f...
متن کاملParent-of-origin effects in SOX2 anophthalmia syndrome
PURPOSE Sex determining region Y (SRY)-box 2 (SOX2) anophthalmia syndrome is an autosomal dominant disorder manifesting as severe developmental eye malformations associated with brain, esophageal, genital, and kidney abnormalities. The syndrome is usually caused by de novo mutations or deletions in the transcription factor SOX2. To investigate any potential parental susceptibility factors, we s...
متن کاملQuantitative trait loci with parent-of-origin effects in chicken.
We investigated potential effects of parent-of-origin specific quantitative trait loci (QTL) in chicken. Two divergent egg-layer lines differing in egg quality were reciprocally crossed to produce 305 F2 hens. Searching the genome using models with uni-parental expression, we identified four genome-wide significant QTL with parent-of-origin effects and three highly suggestive QTL affecting age ...
متن کاملParent-of-origin effects on seed development in Arabidopsis thaliana
Many flowering plants are polyploid, but crosses between individuals of different ploidies produce seeds that develop abnormally and usually abort. Often, seeds from interploidy crosses develop differently depending on whether the mother or father contributes more chromosome sets, suggesting that maternal and paternal genomes are not functionally equivalent. Here we present the first cytologica...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2014
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng.2911